The Geller Lab


Geller R*, Pechmann S*, Acevedo A, Andino R, Frdyman J. Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation. Nature Communications.  May 3;9(1):1781.  doi: 10.1038/s41467-018-04203-x

Geller R*, Pechmann S*, Acevedo A, Andino R, Frdyman J. Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate. BioRxiv, doi:

Geller R, Estada U, Peris JB, Andreu I, Bou JV, Garijo R, Cuevas JM, Sabariegos R, Mas A, Sanjuán R. The hepatitis C virus genome exhibits highly heterogeneous mutation rates. Nat Microbio. 2016 Apr 18. 

Combe M, Garijo R, Geller R, Cuevas JM, Sanjuán R. Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious Units. Cell Host Microbe. 2015 Oct 14;18(4):424-32. 

Geller R*, Domingo-Calap P*, Cuevas JM*, Rossolillo P, Negroni M, Sanjuán R. The external domains of the HIV-1 envelope are a mutational cold spot. Nat Commun. 2015 Oct 9;6:8571. *Shared first authors. 

Cuevas JM*, Geller R*, Garijo R, López-Aldeguer J, Sanjuán R. Extremely High Mutation Rate of HIV-1 In Vivo. PLoS Biol. 2015 Sep 16;13(9):e1002252. *Shared first authors and highlighted in PLoS Biol.    

Geller R, Andino R, Frydman J. Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity against Respiratory Syncytial Virus. PLoS ONE. 2013 Feb 8(2); e56762. 

Chan CT, Reeves RE, Geller R, Yaghoubi SS, Hoehne A, Solow-Cordero DE, Chiosis G, Massoud TF, Paulmurugan R, Gambhir SS. Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects. PNAS. 2012 Sep 11;109(37):E2476-85. 

Geller R, Taguwa S, Frydman J. (2011) Broad action of Hsp90 as a host chaperone required for viral replication. Biochim Biophys Acta. 2012 Mar;1823(3):698-706. 

Geller R, Vignuzzi M, Andino R, Frydman J. (2007) Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance. Genes Dev. 21 (2):195-205. 

Tam S, Geller R, Spiess C, Frydman J. (2006) The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. Nat Cell Biol. 8 (10):1155-62. 

Khakoo SI, Geller R, Shin S, Jenkins JA, Parham P. (2002) The D0 domain of KIR3D acts as a major histocompatibility complex class I binding enhancer. J Exp Med. 196 (7):911-21. 

Geller R, Adams EJ, Guethlein LA, Little AM, Madrigal JA, Parham P. (2002) Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes). Immunogenetics 54 (3):212-5.