The Geller Lab


RNA viruses and cellular host factors:
RNA viruses have to depend on the cellular machinery to carry out many essential function in replication since they have very limited genomic space. We are working to find out which components of the cell are used by respiratory syncytial virus, an important human pathogen, and rhinovirus. The goal here is to better understand viral replication and find targets for antiviral therapy, while hopefully learning something about how humans work in the process.

Harnessing the evolutionary power of RNA viruses via experimental evolution:
RNA viruses have the largest capacity for rapid evolution in nature. This is a big problem for vaccines and antiviral therapies. However, on the positive side, it can be harnessed as an invaluable research tool, helping us learn about both host and viral biology. We are setting up methods to employ viral experimental evolution in our favor.